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Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 357-362 doi: 10.1007/s11684-009-0046-1

Abstract: expression of pituitary tumor transforming gene (PTTG) and basic fibroblast growth factor (bFGF) in oralsquamous cell carcinoma (OSCC) and tongue cancer cell line Tca8113, as well as their effects on each

Keywords： carcinoma     squamous cell     pituitary tumor transforming gene (PTTG) protein     basic fibroblast growth factor    

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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide.inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell

Keywords： benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

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Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 401-410 doi: 10.1007/s11684-013-0286-y

Abstract:

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers

Keywords： esophageal squamous cell carcinoma (ESCC)     early detection     molecular classification     molecular markers    

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p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: mutations have been found in many esophageal squamous cell carcinoma (ESCC) clinical specimens and cellidentified the correlation between p53 functional activation and its genotype in five different ESCC cellTo examine the potential p53 activation in a certain ESCC cell line, DNA damage methods including X-rayinvestigated using Western blot and reverse transcription-polymerase chain reaction (RT-PCR) after cellThe results showed that in KYSE 30 cell line with mutant and KYSE 150 with wild-type , p53 could be

Keywords： p53     esophageal squamous cell carcinoma     DNA damage    

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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamouscell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: Treating patients with esophageal squamous cell carcinoma (ESCC) is challenging due to the high chemoresistanceGDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylation

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 478-486 doi: 10.1007/s11684-015-0420-0

Abstract: telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamouscell carcinoma (ESCC) was still uncertain.

Keywords： esophageal squamous cell carcinoma     telomere length     genetic variants     susceptibility     genome-wide association    

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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: bioinformatics have begun to reveal the complex genetic landscape in human cancer genomes, including oralsquamous cell carcinoma (OSCC).

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oralsquamous cell carcinoma    

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Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 401-413 doi: 10.1007/s11684-011-0161-7

Abstract: Regenerative medicine, based on stem cell science and tissue engineering technology, is considered asIn this paper, we review the current choices of cell source and strategies on directing the osteogenicpreclinical animal models for bone regeneration and the key translational points to clinical success in oralWe propose comprehensive strategies based on stem cell and tissue engineering researches, allowing forclinical application in oral and maxillofacial region.

Keywords： bone regeneration     animal models     translational strategies     oral and maxillofacial region    

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Clinical response with functional image during radiotherapy of esophageal squamous cell carcinoma

Yu Jinming

Strategic Study of CAE 2012, Volume 14, Issue 7,   Pages 9-19

Abstract:

18F-FLT uptake can be used to monitor the biological response of esophageal SCC and normal tissue to RT. Increased uptake of 18F-FLT following treatment interruptions may reflect accelerated repopulation. 18F-FLT PET may have advantages compared to 18F-FDG PET in differentiating inflammation from tumor. 18F-FLT PET may help oncologists predict treatment response as early as one week after the beginning of treatment and estimate clonogenic repopulation during RT. 18F-FETNIM PET can depict hypoxia in esophageal SCC. Prior to CCRT, tumor hypoxia demonstrates spatial variability in different days, though overall 18F-FETNIM uptake remains similar. Baseline SUVmax may be predictive of treatment response.

Keywords： esophageal carcinoma     radiotherapy     positron emission     tomography accelerated repopulation     hypoxia    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 815-826 doi: 10.1007/s11684-021-0891-0

Abstract: Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL)Still, no guidelines or consensus focusing on oral drug therapies for BCL is available.Hematology, Chinese Medical Association conducted an extensive discussion and reached a consensus on oraldrugs for Chinese BCL patients on the basis of the current application status of oral drugs in ChinaThis consensus reviewed the application of oral drugs in the treatment of BCL and the latest research

Keywords： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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Genomic variations in the counterpart normal controls of lung squamous cell carcinomas

Dalin Zhang, Liwei Qu, Bo Zhou, Guizhen Wang, Guangbiao Zhou

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 280-288 doi: 10.1007/s11684-017-0580-1

Abstract:

Lung squamous cell carcinoma (LUSC) causes approximately 400 000 deaths each year worldwide.study, we sequenced the whole genomes of three normal lung tissue samples and their paired adjacent squamouscell carcinomas.

Keywords： lung cancer     counterpart normal control     genomic variations    

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Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 9-19 doi: 10.1007/s11705-013-1306-9

Abstract: Oral insulin delivery has received the most attention in insulin formulations due to its high patientHowever, oral insulin delivery has two major limitations: the enzymatic barrier that leads to rapid insulinmajor success in overcoming the mucosal barrier, which is the main cause in undercutting insulin’s oralwith encapsulated-insulin/cell penetrating peptide (CPP) to overcome both enzyme and mucosal barriersIt was also confirmed that low molecular weight protamine (LMWP) behaves like a CPP peptide, with a cell

Keywords： insulin     cell penetrating peptide     mucoadhesive composites     oral delivery    

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Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: Nasopharyngeal carcinoma (NPC) is a malignant tumor that mainly occurs in East and Southeast Asia.RFC4 knockdown induced G2/M cell cycle arrest and inhibited NPC cell proliferation in vitro anddownstream target of RFC4, and the overexpression of HOXA10 attenuated the silencing of RFC4-induced cellproliferation, colony formation inhibition, and cell cycle arrest.For the first time, this study reveals that RFC4 is required for NPC cell proliferation and may play

Keywords： nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial

Keywords： ALDOB     kidney cancer     cell proliferation    

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Small cell carcinoma of the urinary bladder without gross hematuria: a case report

Wanqiu Huang,Yang Luan,Lu Jin,Tao Wang,Ruibao Chen,Zheng Liu,Zhiqiang Chen,Ruzhu Lan

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 384-387 doi: 10.1007/s11684-015-0405-z

Abstract:

Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancer

Keywords： carcinoma     small cell     urinary bladder neoplasms     diagnosis    

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Title Author Date Type Operation

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Journal Article

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Journal Article

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamouscell carcinoma

Journal Article

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Journal Article

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Journal Article

Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Journal Article

Clinical response with functional image during radiotherapy of esophageal squamous cell carcinoma

Yu Jinming

Journal Article

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Journal Article

Genomic variations in the counterpart normal controls of lung squamous cell carcinomas

Dalin Zhang, Liwei Qu, Bo Zhou, Guizhen Wang, Guangbiao Zhou

Journal Article

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Journal Article

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

Small cell carcinoma of the urinary bladder without gross hematuria: a case report

Wanqiu Huang,Yang Luan,Lu Jin,Tao Wang,Ruibao Chen,Zheng Liu,Zhiqiang Chen,Ruzhu Lan

Journal Article